Berkeley DB requires only underlying IEEE/ANSI Std 1003.1 (POSIX) system calls and can be ported easily to new architectures by adding stub routines to connect the native system interfaces to the Berkeley DB POSIX-style system calls. See Porting Berkeley DB to new architectures for more information.

Berkeley DB will autoconfigure and run on almost any modern UNIX, POSIX or Linux systems, and on most historical UNIX platforms. Berkeley DB will autoconfigure and run on almost any GNU gcc toolchain-based embedded platform, including Cygwin, OpenLinux and others. See Building for UNIX/POSIX for more information.

The Berkeley DB distribution includes support for QNX Neutrino. See Building for UNIX/POSIX for more information.

The Berkeley DB distribution includes support for VxWorks. See Building for VxWorks 6.x for more information.

The Berkeley DB distribution includes support for Windows/NT, Windows/2000 and Windows/XP, via the Microsoft Visual C++ 6.0 and .NET development environments. See Building Berkeley DB for Windows for more information.